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nanolysis

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A sandwich of nanoparticles is formed across the cell membrane. The dipole formation causes a pinching effect of a weak external field causing no harm to other cells but renders the target cell without an electrochemical gradient due to severe pore formations in the membrane

How does the nanolysis by surface plasmon resonance field enhancement work

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BINDING

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The nanoparticles has to be brought to the target cell typically by injection near an infected site or in the vincinity of a tumour. This reduces the systemic concentration of nanoparticles and suppresses any severe immune reactions. At location they have to bind, either extracellularly, intracellularly or a combination of both

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FIELD APPLICATION

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Once in location which can be checked by magnetic resonance imaging for tumors or fluorescence in wounds for bacterial infections, the field is applied causing a surface plasmon resonance enhancement of the dipole field between the two nanoparticles.

PORE FORMATION

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The surface plasmon enhanced field in the dipole causes instant pore formation in the target cell membrane called electroporation, cells without the nanoparticle sandwich is not affected as severely as the targetted cell

IRREVERSIBLE PORES

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Pore formation continues as long as the field is on, and reverses after the field is removed. However, some pores do not reverse, they merge and become so large that they cause instant loss of any electro-chemical gradient across the lipid bilayer membrane – this is equal to the death of the target cell

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The nanoparticles can be injected into or near the site of infection or in the vincinity of a tumor or directly into the tumor to maximize the load of particles in the disease effected area and minimizing the systemic dose which if too high can lead to unwanted immune responses

Gold particles

The nanoparticles are constructed with an outer shell of gold allowing precison laser binding of biomolecules to the surface of the nanoparticle. Hereto, the gold creates a very strong surface plasmon resonance effect

Size of particles and clearance from the body

The nanoparticles are typically below 40 nm The removal of nanoparticles from the body involves a coordinated effort by the renal system, liver, and immune system.

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The patented nanolysis technique can be tailored to any cell type and multiple target selections can be made on a single cell without the need for an associated biochemical effect

Multiple targets per cell

Several intracellular and extracellular targets can be chosen optimizing the effect on the target cells and reducing the effect on non-target cells

Loading of cells

Cells with high sugar consumption as e.g. bacteria and cancer cells can be loaded with multiple intracellular particles enhancing the effect by extracellular bound particles. This offers a way for using high metabolism of bacteria and cancer cells as a differentiating factor in obtaining a precise effect on only target cells.

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The nanolysis technique uses specially designed electronics by Gnacode to achieve the maximal effect on the nanostructures on the target cells

High Speed

The high-frequency fields reduces the time needed for activating the nanolysis and for causing cell death in target cells. This ensures that minimal damage is done to the surrounding techniques, making the nanolysis a gentler process compared to e.g. thermal ablation by nanoparticles

Fast Treatments

The overall speed of the technology, combined with direct injection of nanoparticles into the affected area makes the nanolysis technique one of the fastest treatments in the market.

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